Mosquito heat seeking is driven by an ancestral cooling receptor

Chloe Greppi; Willem J Laursen; Gonzalo Budelli; Elaine C Chang; Abigail M Daniels; Lena van Giesen; Andrea L Smidler; Flaminia Catteruccia; Paul A Garrity

doi:10.1126/science.aay9847

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Mosquito heat seeking is driven by an ancestral cooling receptor

Journal article

Peer reviewed

Mosquito heat seeking is driven by an ancestral cooling receptor

Chloe Greppi, Willem J Laursen, Gonzalo Budelli, Elaine C Chang, Abigail M Daniels, Lena van Giesen, Andrea L Smidler, Flaminia Catteruccia and Paul A Garrity

Science (American Association for the Advancement of Science), Vol.367(6478), pp.681-684

02/07/2020

DOI: https://doi.org/10.1126/science.aay9847

PMID: 32029627

Abstract

Host-Seeking Behavior - physiology

Receptors, Ionotropic Glutamate - physiology

Anopheles - genetics

Receptors, Ionotropic Glutamate - genetics

Hot Temperature

Body Temperature

Anopheles - physiology

Blood

Thermoreceptors - physiology

Animals

Female

Mice

Evolution, Molecular

Mutation

Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown. Here, we identify ionotropic receptor IR21a, a receptor conserved throughout insects, as a key mediator of heat seeking in the malaria vector Although mediates heat avoidance in , we find it drives heat seeking and heat-stimulated blood feeding in At a cellular level, is essential for the detection of cooling, suggesting that during evolution mosquito heat seeking relied on cooling-mediated repulsion. Our data indicate that the evolution of blood feeding in involves repurposing an ancestral thermoreceptor from non-blood-feeding Diptera.

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Title: Mosquito heat seeking is driven by an ancestral cooling receptor
Creators: Chloe Greppi - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Willem J Laursen - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Gonzalo Budelli - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Elaine C Chang - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Abigail M Daniels - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Lena van Giesen - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA
Andrea L Smidler - Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115, USA
Flaminia Catteruccia - Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
Paul A Garrity - Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA. pgarrity@brandeis.edu
Publication Details: Science (American Association for the Advancement of Science), Vol.367(6478), pp.681-684
Publisher: United States
Grant note: R01 AI122802 / NIAID NIH HHS F32 GM113318 / NIGMS NIH HHS Howard Hughes Medical Institute F31 AI133945 / NIAID NIH HHS R21 AI140018 / NIAID NIH HHS T32 NS007292 / NINDS NIH HHS
Identifiers: 9923977489101921
Academic Unit: Interdepartmental Program in Neuroscience; Department of Biology; Benjamin and Mae Volen National Center for Complex Systems
Language: English
Resource Type: Journal article

Mosquito heat seeking is driven by an ancestral cooling receptor

Abstract

UN Sustainable Development Goals (SDGs)

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