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Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method
Book chapter   Peer reviewed

Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method

Dagmar Ringe and Carla Mattos
Fragment‐based Approaches in Drug Discovery, pp.67-88
Wiley‐VCH Verlag GmbH & Co. KGaA
07/20/2006

Abstract

functional characterization of proteins computational methods multiple solvent crystal structure method organic solvent binding sites other solvent mapping experiments concept internal waters protein–ligand binding sites surface waters structures of elastase in nonaqueous solvents conservation of water binding sites solvent mapping drug discovery binding of water molecules location of binding sites on proteins surface of a protein theory

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