The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes

Tom Alberi; William A Gilbert; Dagmar Ringe Ponzi; Gregory A Petsko

doi:10.1002/9780470720752.ch2

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The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes

Book chapter

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The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes

Tom Alberi, William A Gilbert, Dagmar Ringe Ponzi and Gregory A Petsko

Ciba Foundation Symposium 93 ‐ Mobility and Function in Proteins and Nucleic Acids, pp.4-24

John Wiley & Sons, Ltd

01/01/1983

DOI: https://doi.org/10.1002/9780470720752.ch2

Abstract

mobility

catalytic machinery

michaelis complex

ribonuclease

Enzymes

This chapter contains section titled: Enzymes As Machines Proteins are Flexible in the Crystalline State The Problem of Ligand Access The Problem of Response to Changing Substrate Structure When Tight Binding is Not So Tight Directed Fluctuations: Fact or Fantasy? Conclusion: Enzyme Mobility is Important for Enzyme Function References

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Title: The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes
Creators: Tom Alberi - Departments of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
William A Gilbert - Departments of chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Dagmar Ringe Ponzi - Departments of chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Gregory A Petsko - Departments of chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Contributors: Ruth Porter (Editor)
Maeve O'Connor (Editor)
Julie Whelan (Editor)
Publication Details: Ciba Foundation Symposium 93 ‐ Mobility and Function in Proteins and Nucleic Acids, pp.4-24
Publisher: John Wiley & Sons, Ltd; Chichester, UK
Number of pages: 21
Identifiers: 9923972802701921
Academic Unit: Department of Chemistry; Rosenstiel Basic Medical Sciences Research Center; Interdepartmental Program in Neuroscience; Department of Biochemistry
Language: English
Resource Type: Book chapter

The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes

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