Coordination between transcription and pre-mRNA processing

P Cramer; A Srebrow; S Kadener; S Werbajh; M de la Mata; G Melen; G Nogués; A.R Kornblihtt

doi:10.1016/S0014-5793(01)02485-1

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Coordination between transcription and pre-mRNA processing

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Coordination between transcription and pre-mRNA processing

P Cramer, A Srebrow, S Kadener, S Werbajh, M de la Mata, G Melen, G Nogués and A.R Kornblihtt

FEBS Letters, Vol.498(2), pp.179-182

06/08/2001

DOI: https://doi.org/10.1016/S0014-5793(01)02485-1

PMID: 11412852

Abstract

Carboxy-terminal domain

Coupling

mRNA processing

RNA polymerase II

A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.

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Title: Coordination between transcription and pre-mRNA processing
Creators: P Cramer - Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
A Srebrow - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
S Kadener - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
S Werbajh - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
M de la Mata - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
G Melen - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
G Nogués - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
A.R Kornblihtt - Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina
Publication Details: FEBS Letters, Vol.498(2), pp.179-182
Publisher: Elsevier B.V
Identifiers: 9923958302401921
Academic Unit: Rosenstiel Basic Medical Sciences Research Center; Department of Biology; Benjamin and Mae Volen National Center for Complex Systems; Interdepartmental Program in Neuroscience
Language: English
Resource Type: Review

Coordination between transcription and pre-mRNA processing

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