Abstract
Clinical Decision-Support (CDS) systems are architected to resolve knowledge-intensive tasks for supporting decision-making processes in the medical fields and the healthcare industry. Furthermore, CDS systems are expected to promote and contribute to the drug discovery process in pharmaceutical companies, while the CDS system can be connected and collaborated with electronic health record (EHR). However, current solutions for CDS are not well-established across different organizations and institutions in information societies because of high implementation costs and various, complex decision-making problems by medical staffs. In this paper, we suggest that the reference architecture and framework for the CDS system with EHR will be proposed and verified by the case in a hospital. In addition, the challenge and future activities for this area are expressed.