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Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine
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Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine

Xiaofeng Liu, Hongming Li and Li Deng
Figshare
01/01/2016

Abstract

alkaloids carbonyl Chiral Catalysts Accessible cinchona compound construction creation Cyanoacetate disubstituted Enantioselective Amination Plant Biology quaternary quinidine quinine S configuration stereocenter Substituted synthesis task Biotechnology Developmental Biology Ecology Evolutionary Biology Genetics Immunology Organic Chemistry Sociology
The catalytic construction of nitrogen-substituted quaternary stereocenters is an important and challenging task in asymmetric synthesis. In this paper, we describe the use of 6‘-OH-modified cinchona alkaloids that are accessible from either quinine or quinidine for the development of a highly enantioselective amination of α,α-disubstituted carbonyl compounds that is suitable for the creation of nitrogen-substituted quaternary stereocenters in either the R or S configuration.

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