Abstract
Unlike conventional materials that covalent bonds connecting atoms are the major force to hold the materials together, supramolecular biomaterials rely on noncovalent intermolecular interactions to assemble. The reversibility and biocompatibility of supramolecular biomaterials render them with diverse range of functions and lead to rapid development in the past two decades. This thesis focuses on exploring the noncovalent and enzymatic/nonenzymatic mechanisms governing the regulation of supramolecular biomaterials, aiming to control self-assembly for diverse biomedical applications. Each chapter of this thesis highlights exemplary applications of supramolecular biomaterials across three distinct categories: tissue engineering, cancer therapy, and drug delivery. Through the exploration of these applications, the works in the thesis intend to show that enzymatic control of intermolecular interactions is a powerful tool for achieving spatiotemporal control both in vitro and in vivo.