Abstract
Twelve novel compounds were synthesized by the [3+2] 1,3‐dipolar cycloaddition reaction of 5,6‐dehydronorcantharidin derivatives of substituted aromatic amines with nitrile oxides. The structure and the configuration of all compounds were confirmed by 1H NMR, IR, MS, 1H‐1HCOSY, and NOESY spectral data. Their anti‐tumor activities are under way.