2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter

Chen-Chen Peng; Zhi Li; Li-Qun Deng; Zhuo-Feng Ke; Wen-Hua Chen

doi:10.1016/j.bmcl.2016.03.114

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2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter

Journal article

Peer reviewed

2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter

Chen-Chen Peng, Zhi Li, Li-Qun Deng, Zhuo-Feng Ke and Wen-Hua Chen

Bioorganic & medicinal chemistry letters, Vol.26(10), pp.2442-2445

05/15/2016

DOI: https://doi.org/10.1016/j.bmcl.2016.03.114

PMID: 27072911

Abstract

Anionophore

Benzimidazole

Anionophoric activity

Ion selectivity

2,6-Bis(benzimidazol-2-yl)pyridine was shown to exhibit potent anionophoric activity via a process of both Cl−/NO3− antiport and H+/Cl− symport. This is in sharp contrast to the finding that its corresponding N-methylated analog exhibited negligible activity and reveals the importance of the imidazolyl-NH fragments in the anion-transport process.

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Title: 2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter
Creators: Chen-Chen Peng - Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
Zhi Li - Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
Li-Qun Deng - Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
Zhuo-Feng Ke - School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, PR China
Wen-Hua Chen - Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
Publication Details: Bioorganic & medicinal chemistry letters, Vol.26(10), pp.2442-2445
Publisher: Elsevier Ltd
Identifiers: 9923972828201921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter

Abstract

UN Sustainable Development Goals (SDGs)

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