A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation

Jerome S Menet; Michael Rosbash

doi:10.1016/j.molcel.2011.08.015

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A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation

Journal article

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A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation

Jerome S Menet and Michael Rosbash

Molecular cell, Vol.43(5), pp.695-697

2011

DOI: https://doi.org/10.1016/j.molcel.2011.08.015

PMID: 21884970

Abstract

Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth et al. (2011) demonstrate that phosphorylation of Neurospora FRQ induces a conformational change, which can account for its temporally gated degradation.

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Title: A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation
Creators: Jerome S Menet - Department of Biology, National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Michael Rosbash - Department of Biology, National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Publication Details: Molecular cell, Vol.43(5), pp.695-697
Publisher: Elsevier Inc
Identifiers: 9923957843001921
Academic Unit: Department of Biology; Benjamin and Mae Volen National Center for Complex Systems; Interdepartmental Program in Neuroscience
Language: English
Resource Type: Journal article

A New Twist on Clock Protein Phosphorylation: A Conformational Change Leads to Protein Degradation

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