Abstract
Getting AMPA receptors into and out of synapses represents an important mechanism for changing synaptic strength, but the signals that target AMPA receptors for removal from the synaptic membrane are incompletely understood. A recent study in
Ceanorhabditis elegans suggests that ubiquitination of AMPA receptors is one important signal that targets these receptors for endocytosis.
A novel role for ubiquitin in AMPA-receptor endocytosis suggests that ubiquitination could be an important mechanism underlying plastic changes in synaptic strength.