Abstract
report that the DNA breaks that provoke chromothripsis--the pulverization and dramatic assembly into a rearranged chromosome--are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids. Author Affiliation: (1) Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02154, USA * Corresponding author Byline: James E. Haber [haber@brandeis.edu] (1,*)
