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An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite
Journal article   Peer reviewed

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

T. A Zeidan, J. T Trotta, P. A Tilak, M. A Oliveira, R. A Chiarella, B. M Foxman, Ö Almarsson and M. B Hickey
CrystEngComm, Vol.18(9), pp.1486-1488
2016

Abstract

A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.

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