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Asymmetric Synthesis of Chiral Aldehydes by Conjugate Additions with Bifunctional Organocatalysis by Cinchona Alkaloids
Journal article   Peer reviewed

Asymmetric Synthesis of Chiral Aldehydes by Conjugate Additions with Bifunctional Organocatalysis by Cinchona Alkaloids

Fanghui Wu, Ran Hong, Jihan Khan, Xiaofeng Liu and Li Deng
Angewandte Chemie (International ed.), Vol.45(26), pp.4301-4305
06/26/2006
PMID: 16739143

Abstract

organocatalysis aldehydes conjugate addition alkaloids Natural Products Organic Chemistry
A highly efficient asymmetric conjugate addition of carbonyl donors to α,β‐unsaturated aldehydes is realized with 6′‐OH cinchona alkaloids as bifunctional organocatalysts. A wide range of α‐substituted β‐ketoesters and α‐substituted α‐cyanoacetates can be employed as donors, whereas acrolein and β‐substituted α,β‐unsaturated aldehydes are suitable acceptors for this enantioselective addition.

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