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Axon targeting meets protein trafficking: Comm takes Robo to the cleaners
Journal article   Open access   Peer reviewed

Axon targeting meets protein trafficking: Comm takes Robo to the cleaners

Mark Rosenzweig and Paul Garrity
Developmental cell, Vol.3(3), pp.301-302
09/2002
DOI: https://doi.org/10.1016/S1534-5807(02)00260-5
PMID: 12361590

Abstract

Receptors, Immunologic - physiology Axons - physiology Central Nervous System - embryology Drosophila - physiology Endosomes - metabolism Functional Laterality - genetics Central Nervous System - physiology Cell Differentiation - genetics Gene Expression Regulation, Developmental Membrane Proteins - physiology Drosophila - embryology Receptors, Cell Surface - physiology Embryo, Nonmammalian - physiology Drosophila Proteins Endosomes - genetics Drosophila - cytology Cell Communication - genetics Protein Transport Nerve Tissue Proteins - metabolism Animals Central Nervous System - cytology Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Cell Surface - genetics Gene Expression Signal Transduction Ligands
Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway.
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https://doi.org/10.1016/S1534-5807(02)00260-5View
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