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CaMKII: new tricks for an old dog
Journal article   Open access   Peer reviewed

CaMKII: new tricks for an old dog

Leslie C Griffith
Cell (Cambridge), Vol.133(3), pp.397-399
05/02/2008
DOI: https://doi.org/10.1016/j.cell.2008.04.018
PMCID: PMC2655315
PMID: 18455979

Abstract

Animals Reactive Oxygen Species - metabolism Heart Diseases - metabolism Humans Myocytes, Cardiac - metabolism Enzyme Activation Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal signaling molecule in both the brain and the heart. In this issue of Cell, Erickson et al. (2008) demonstrate a mechanism for CaMKII activation by reactive oxygen species that provides a direct link between kinase activation and cardiac dysfunction.
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https://doi.org/10.1016/j.cell.2008.04.018View
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