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Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein
Journal article   Open access   Peer reviewed

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein

Wei Wang, Linh T T Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S Fisher, David W Miller, Debajyoti Datta, …
Proceedings of the National Academy of Sciences - PNAS, Vol.113(34), pp.9587-9592
08/23/2016
PMCID: PMC5003239
PMID: 27482083

Abstract

Neurons - pathology RNA, Small Interfering - genetics Inflammasomes - metabolism Lewy Bodies - drug effects para-Aminobenzoates - pharmacology Humans Caspase 1 - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Protein Aggregates - genetics Neurons - metabolism alpha-Synuclein - genetics Lewy Bodies - metabolism Neurons - drug effects Lewy Bodies - pathology Cell Survival - drug effects Dipeptides - pharmacology Gene Expression Regulation Alum Compounds - pharmacology alpha-Synuclein - chemistry Vitamin K 3 - pharmacology Caspase 1 - genetics Lipopolysaccharides - pharmacology Cell Line, Tumor Nigericin - pharmacology alpha-Synuclein - metabolism RNA, Small Interfering - metabolism Signal Transduction

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#3 Good Health and Well-Being
url
https://doi.org/10.1073/pnas.1610099113View
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