Logo image
 Home Academic units
Sign in
Back
Cell biology. TAPping into mRNA export
Journal article   Peer reviewed

Cell biology. TAPping into mRNA export

M J Moore and M Rosbash
Science (American Association for the Advancement of Science), Vol.294(5548), pp.1841-1842
11/30/2001
DOI: https://doi.org/10.1126/science.1067676
PMID: 11729289

Abstract

ELAV-Like Protein 1 Nucleocytoplasmic Transport Proteins Homeodomain Proteins - metabolism Humans Cell Membrane Permeability Cytoplasm - metabolism Peptide Fragments - pharmacology Antennapedia Homeodomain Protein RNA, Messenger - metabolism ELAV Proteins Receptors, Cytoplasmic and Nuclear Gene Products, rev - metabolism Cell Nucleus - metabolism Protein Binding - drug effects Gene Products, rev - chemistry Biological Transport - drug effects RNA-Binding Proteins - antagonists & inhibitors Protein Structure, Tertiary Peptide Fragments - metabolism RNA, Messenger - genetics RNA-Binding Proteins - chemistry Fatty Acids, Unsaturated - pharmacology Neuropeptides - metabolism Nuclear Proteins - metabolism Fatty Acids, Unsaturated - metabolism Homeodomain Proteins - chemistry Peptide Fragments - chemistry Animals Karyopherins - metabolism Saccharomyces cerevisiae Proteins - metabolism rev Gene Products, Human Immunodeficiency Virus HIV - genetics Antigens, Surface Transcription Factors Cell Nucleus - drug effects Cytoplasm - drug effects RNA-Binding Proteins - metabolism
There seem to be numerous pathways for exporting mRNAs from the nucleus to the cytoplasm. But working out which set of export adaptors and receptors transport individual mRNAs has been very difficult. In a Perspective, Moore and Rosbash discuss a new strategy using cell-penetrating peptide inhibitors for unraveling the routes of mRNA export in living cells (Gallouzi and Steitz).

Metrics

37 Record Views

Details