Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Katharine C. Abruzzi; Cedric Gobet; Felix Naef; Michael Rosbash

doi:10.1126/science.abf0922

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Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Journal article

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Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Katharine C. Abruzzi, Cedric Gobet, Felix Naef and Michael Rosbash

Science (American Association for the Advancement of Science), Vol.372(6539), 0922

04/16/2021

DOI: https://doi.org/10.1126/science.abf0922

PMID: 33859000

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.

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Title: Comment on "Circadian rhythms in the absence of the clock gene Bmal1"
Creators: Katharine C. Abruzzi - Brandeis University, Department of Biology
Cedric Gobet - Ecole Polytech Fed Lausanne, Inst Bioengn, Sch Life Sci, CH-1015 Lausanne, Switzerland
Felix Naef - Ecole Polytech Fed Lausanne, Inst Bioengn, Sch Life Sci, CH-1015 Lausanne, Switzerland
Michael Rosbash - Brandeis University, Department of Biology
Publication Details: Science (American Association for the Advancement of Science), Vol.372(6539), 0922
Publisher: Amer Assoc Advancement Science
Number of pages: 5
Grant note: 310030_173079 / Swiss National Science Foundation (SNF); Swiss National Science Foundation (SNSF) Howard Hughes Medical Institute EPFL 310030_173079 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF)
Identifiers: 9924552854801921
Academic Unit: Neuroscience Program; Department of Biology; Benjamin and Mae Volen National Center for Complex Systems
Language: English
Resource Type: Journal article

Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

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