Abstract
In the light of recently disclosed crystallographic studies on migrastatin ketone
2 complex with fascin, the structures of migrastatin ketone
2 and migrastatin ether
4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the ‘small molecule’ co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.