Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

Lisa C Ryner; Stephen F Goodwin; Diego H Castrillon; Anuranjan Anand; Adriana Villella; Bruce S Baker; Jeffrey C Hall; Barbara J Taylor; Steven A Wasserman

doi:10.1016/S0092-8674(00)81802-4

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Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

Journal article

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Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

Lisa C Ryner, Stephen F Goodwin, Diego H Castrillon, Anuranjan Anand, Adriana Villella, Bruce S Baker, Jeffrey C Hall, Barbara J Taylor and Steven A Wasserman

Cell (Cambridge), Vol.87(6), pp.1079-1089

12/13/1996

DOI: https://doi.org/10.1016/S0092-8674(00)81802-4

PMID: 8978612

Abstract

Drosophila

fruitless

central nervous system

Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-determination hierarchy functioning specifically in the central nervous system (CNS). The phenotypes of new fru mutants encompass nearly all aspects of male sexual behavior. Alternative splicing of fru transcripts produces sex-specific proteins belonging to the BTB-ZF family of transcriptional regulators. The sex-specific fru products are produced in only about 500 of the 10 5 neurons that comprise the CNS. The properties of neurons expressing these fru products suggest that fru specifies the fates or activities of neurons that carry out higher order control functions to elicit and coordinate the activities comprising male courtship behavior.

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Title: Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
Creators: Lisa C Ryner - Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Stephen F Goodwin - Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
Diego H Castrillon - Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
Anuranjan Anand - Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Adriana Villella - Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
Bruce S Baker - Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
Jeffrey C Hall - Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
Barbara J Taylor - Department of Zoology, Oregon State University, Corvallis, Oregon 97331, USA
Steven A Wasserman - Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
Publication Details: Cell (Cambridge), Vol.87(6), pp.1079-1089
Publisher: Elsevier Inc
Identifiers: 9923982491301921
Academic Unit: Department of Biology
Language: English
Resource Type: Journal article

Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

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