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Development of a rapid, room-temperature dynamic kinetic resolution for efficient asymmetric synthesis of alpha-aryl amino acids
Journal article   Peer reviewed

Development of a rapid, room-temperature dynamic kinetic resolution for efficient asymmetric synthesis of alpha-aryl amino acids

Jianfeng Hang, Hongming Li and Li Deng
Organic letters, Vol.4(19), pp.3321-3324
09/01/2002
DOI: https://doi.org/10.1021/ol026660l
PMID: 12227779

Abstract

Temperature Stereoisomerism Amino Acids - chemistry Molecular Structure Amino Acids - chemical synthesis Catalysis Kinetics
A rapid, highly efficient and general dynamic kinetic resolution (DKR) of racemic alpha-aryl UNCAs with the dual-function catalysis of modified cinchona alkaloid was accomplished at room temperature. This DKR led to the development of a highly enantioselective catalytic method for the practical synthesis of a wide range of alpha-aryl and alpha-heteroaryl amino acids in 89-92% ee and 86-95% yield from racemic UNCAs.

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