Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

Thordur Oskarsson; Pavel Nagorny; Isaac Krauss; Lucy Perez; Mihiribaran Mandal; Guangli Yang; Ouathek Ouerfelli; Danhua Xiao; Malcolm Moore; Joan Massagué; Samuel J Danishefsky

doi:10.1021/ja9101503

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Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

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Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

Thordur Oskarsson, Pavel Nagorny, Isaac Krauss, Lucy Perez, Mihiribaran Mandal, Guangli Yang, Ouathek Ouerfelli, Danhua Xiao, Malcolm Moore, Joan Massagué, …

Journal of the American Chemical Society, Vol.132(9), pp.3224-3228

03/10/2010

DOI: https://doi.org/10.1021/ja9101503

PMCID: PMC2863049

PMID: 20155906

Abstract

Rodent models

Cells

Cancer

Cell Physiology

Genetics

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.

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Title: Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog
Creators: Thordur Oskarsson - Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Pavel Nagorny - Laboratory for Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Isaac Krauss - Laboratory for Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Lucy Perez - Laboratory for Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Mihiribaran Mandal - Laboratory for Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Guangli Yang - Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Ouathek Ouerfelli - Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Danhua Xiao - Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Malcolm Moore - Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Joan Massagué - Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Samuel J Danishefsky - Laboratory for Bioorganic Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065
Publication Details: Journal of the American Chemical Society, Vol.132(9), pp.3224-3228
Identifiers: 9923958293101921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

Abstract

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