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Do vanadate polyanions inhibit phosphotransferase enzymes?
Journal article

Do vanadate polyanions inhibit phosphotransferase enzymes?

Donald W Boyd, Kenneth Kustin and Maho Niwa
Biochimica et biophysica acta, Protein structure and molecular enzymology, Vol.827(3), pp.472-475
03/01/1985
PMID: 2982413

Abstract

Vanadate polyanion Phosphotransferase inhibition
Decavanadate inhibits hexokinase, adenylate kinase and phosphofructokinase; neither mono-, tri nor tetrameric vanadate anion is an inhibitor. Decavanadate inhibits phosphofructokinase obtained from bacterial and protistic sources. No form of vanadium(V) anion inhibits galacto-, glycero-, pyruvate and creatine kinase, or inorganic pyrophosphatase. Decavanadate appears to be a non-competitive inhibitor of both hexokinase substrates.

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