Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y Fatieiev; J. G Croissant; K Julfakyan; L Deng; D. H Anjum; A Gurinov; N. M Khashab

doi:10.1039/C5NR03065J

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Journal article

Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y Fatieiev, J. G Croissant, K Julfakyan, L Deng, D. H Anjum, A Gurinov and N. M Khashab

Nanoscale, Vol.7(37), pp.15046-15050

2015

DOI: https://doi.org/10.1039/C5NR03065J

PMID: 26165456

Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

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Title: Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging
Creators: Y Fatieiev - Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia
J. G Croissant - Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia
K Julfakyan - Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia
L Deng - Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia
D. H Anjum - Advanced Nanofabrication, Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
A Gurinov - Advanced Nanofabrication, Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
N. M Khashab - Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia
Publication Details: Nanoscale, Vol.7(37), pp.15046-15050
Identifiers: 9923972944401921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

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