Abstract
Modern structural biology, driven by X-ray crystallography, electron microscopy, nuclear magnetic resonance (NMR) and computational structure prediction, has revolutionized the visualization of biological macromolecules at atomic resolution. The speed of structure determination, the accuracy, the increasing complexity and size, and finally the beauty of biological structures are simply mind-blowing. Yet such static snapshots usually do not adequately address the question of function, as they primarily capture the most populated, lowest energy structures. Crucially, the secret of protein function lies in their dynamic nature.