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Global resource distribution: allocation of actin building blocks by profilin
Journal article   Open access   Peer reviewed

Global resource distribution: allocation of actin building blocks by profilin

Jessica L Henty-Ridilla and Bruce L Goode
Developmental cell, Vol.32(1), pp.5-6
01/12/2015
DOI: https://doi.org/10.1016/j.devcel.2014.12.022
PMID: 25584793

Abstract

Schizosaccharomyces - metabolism Actin-Related Protein 2-3 Complex - metabolism Actin Cytoskeleton - metabolism Animals Homeostasis - physiology Actins - metabolism Schizosaccharomyces pombe Proteins - metabolism Female Male Profilins - metabolism
How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.
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https://doi.org/10.1016/j.devcel.2014.12.022View
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