Halogenated analogs of tri- O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies

Jallal M Gnaim; Philip M Keehn; Bernard S Green

doi:10.1016/S0040-4039(00)78886-1

Back

Halogenated analogs of tri- O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies

Journal article

Peer reviewed

Halogenated analogs of tri- O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies

Jallal M Gnaim, Philip M Keehn and Bernard S Green

Tetrahedron letters, Vol.33(20), pp.2883-2886

05/12/1992

DOI: https://doi.org/10.1016/S0040-4039(00)78886-1

Abstract

Halogenated trisalicylide derivatives 1-6, representing three-fold symmetric C3 “home trimmers” as well as dissymmetric C1 “mixed trimers” have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen was demonstrated for analog 2, providing a new entry to TOT-based host molecules. Halogenated TOT and TSBS have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen provided a new entry to TOT-based host molecules.

Metrics

19 Record Views

Details

Title: Halogenated analogs of tri- O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies
Creators: Jallal M Gnaim - Department of Pharmaceutical Chemistry, The School of Pharmacy, The Hebrew University, P.O. Box 12065, Jerusalem, 91120 Israel
Philip M Keehn - Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254 U.S.A
Bernard S Green - Department of Pharmaceutical Chemistry, The School of Pharmacy, The Hebrew University, P.O. Box 12065, Jerusalem, 91120 Israel
Publication Details: Tetrahedron letters, Vol.33(20), pp.2883-2886
Publisher: Elsevier Ltd
Identifiers: 9924011605501921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Halogenated analogs of tri- O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies

Abstract

Metrics

Details

Brandeis University Social media