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Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine
Journal article   Peer reviewed

Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine

Xiaofeng Liu, Hongming Li and Li Deng
Organic letters, Vol.7(2), pp.167-169
01/01/2005
DOI: https://doi.org/10.1021/ol048190w
PMID: 15646949

Abstract

Catalysts Hydrocarbons Organic reactions Stereoselectivity Aromatic Compounds
The catalytic construction of nitrogen-substituted quaternary stereocenters is an important and challenging task in asymmetric synthesis. In this paper, we describe the use of 6‘-OH-modified cinchona alkaloids that are accessible from either quinine or quinidine for the development of a highly enantioselective amination of α,α-disubstituted carbonyl compounds that is suitable for the creation of nitrogen-substituted quaternary stereocenters in either the R or S configuration.

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