Hyaluronic acid modified doxorubicin loaded Fe 3 O 4 nanoparticles effectively inhibit breast cancer metastasis

Ting Gong; Zhanglu Dong; Yao Fu; Tao Gong; Li Deng; Zhirong Zhang

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Hyaluronic acid modified doxorubicin loaded Fe 3 O 4 nanoparticles effectively inhibit breast cancer metastasis

Ting Gong, Zhanglu Dong, Yao Fu, Tao Gong, Li Deng and Zhirong Zhang

Journal of materials chemistry. B, Materials for biology and medicine, Vol.7(38), p.5861

10/14/2019

PMID: 31512706

Abstract

Tumor-associated macrophages (TAMs) play a critical role in tumor survival and metastasis. Iron(II,III) oxide (Fe3O4) nanoparticles have been shown to induce M1 macrophage polarization to initiate antitumor immunity and inhibit tumor metastasis. Hyaluronic acid (HA) modified doxorubicin (DOX) loaded Fe3O4 nanoparticles (Fe3O4–DOX–HA) have been constructed to mediate specific delivery of Fe3O4 nanoparticles to CD44-positive 4T1 tumor cells and tumor associated macrophages. Covalent conjugation of HA with DOX rendered nanoparticles with pH sensitivity, and further contributed to the prolonged circulation and enhanced tumor-specific accumulation in vivo. Furthermore, combining the M1 polarization effect of the Fe3O4 nanoparticles and enhanced cytotoxicity, Fe3O4–DOX–HA demonstrated enhanced antitumor and anti-metastasis effects both in vitro and in vivo.

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Title: Hyaluronic acid modified doxorubicin loaded Fe 3 O 4 nanoparticles effectively inhibit breast cancer metastasis
Creators: Ting Gong - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Zhanglu Dong - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Yao Fu - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Tao Gong - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Li Deng - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Zhirong Zhang - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China. denglisunny@163.com
Publication Details: Journal of materials chemistry. B, Materials for biology and medicine, Vol.7(38), p.5861
Publisher: England
Identifiers: 9923972896301921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Hyaluronic acid modified doxorubicin loaded Fe 3 O 4 nanoparticles effectively inhibit breast cancer metastasis

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