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Iron(II)-catalyzed asymmetric intramolecular aminohydroxylation of indoles
Journal article   Peer reviewed

Iron(II)-catalyzed asymmetric intramolecular aminohydroxylation of indoles

Yong-Qiang Zhang, Yong-An Yuan, Guan-Sai Liu and Hao Xu
Organic letters, Vol.15(15), pp.3910-3913
08/02/2013
DOI: https://doi.org/10.1021/ol401666e
PMID: 23875702

Abstract

Hydroxylation Stereoisomerism Iron - chemistry Ferrous Compounds - chemistry Molecular Structure Catalysis Indoles - chemistry
An enantioselective intramolecular indole aminohydroxylation reaction is catalyzed by iron(II)-chiral bisoxazoline (BOX) complexes (ee up to 99%, dr > 20:1). This discovery enables expedient asymmetric synthesis of a series of biologically active 3-amino oxindoles and 3-amino indolanes.

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