Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

Haitao Xiang; Yingze Zhao; Xinyang Li; Peipei Liu; Longlong Wang; Meiniang Wang; Lei Tian; Hai-Xi Sun; Wei Zhang; Ziqian Xu; Beiwei Ye; Xiaoju Yuan; Pengyan Wang; Ning Zhang; Yuhuan Gong; Chengrong Bian; Zhaohai Wang; Linxiang Yu; Jin Yan; Fanping Meng; Changqing Bai; Xiaoshan Wang; Xiaopan Liu; Kai Gao; Liang Wu; Longqi Liu; Ying Gu; Yuhai Bi; Yi Shi; Shaogeng Zhang; Chen Zhu; Xun Xu; Guizhen Wu; George F Gao; Naibo Yang; William J Liu; Penghui Yang

doi:10.1016/j.humimm.2021.10.007

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Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

Journal article

Peer reviewed

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

Haitao Xiang, Yingze Zhao, Xinyang Li, Peipei Liu, Longlong Wang, Meiniang Wang, Lei Tian, Hai-Xi Sun, Wei Zhang, Ziqian Xu, …

Human immunology, Vol.83(2), p.119

02/2022

DOI: https://doi.org/10.1016/j.humimm.2021.10.007

PMID: 34785098

Abstract

COVID-19

SARS-CoV-2

B-cell receptor repertoire

Clonal expansion

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of coronavirus disease 2019 (COVID-19). Great international efforts have been put into the development of prophylactic vaccines and neutralizing antibodies. However, the knowledge about the B cell immune response induced by the SARS-CoV-2 virus is still limited. Here, we report a comprehensive characterization of the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients. By using next-generation sequencing technology, we examined the temporal changes in the landscape of the patient's immunological status and found dramatic changes in the IGH within the patient's immune system after the onset of COVID-19 symptoms. Although different patients have distinct immune responses to SARS-CoV-2 infection, by employing clonotype overlap, lineage expansion, and clonotype network analyses, we observed a higher clonotype overlap and substantial lineage expansion of B cell clones 2-3 weeks after the onset of illness, which is of great importance to B-cell immune responses. Meanwhile, for preferences of V gene usage during SARS-CoV-2 infection, IGHV3-74 and IGHV4-34, and IGHV4-39 in COVID-19 patients were more abundant than those of healthy controls. Overall, we present an immunological resource for SARS-CoV-2 that could promote both therapeutic development as well as mechanistic research.

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Title: Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients
Creators: Haitao Xiang - University of Chinese Academy of Sciences
Yingze Zhao - National Institute for Viral Disease Control and Prevention
Xinyang Li - University of Chinese Academy of Sciences
Peipei Liu - National Institute for Viral Disease Control and Prevention
Longlong Wang - University of Chinese Academy of Sciences
Meiniang Wang - China National GeneBank
Lei Tian - China National GeneBank
Hai-Xi Sun - China National GeneBank
Wei Zhang - City University of Hong Kong
Ziqian Xu - National Institute for Viral Disease Control and Prevention
Beiwei Ye - National Institute for Viral Disease Control and Prevention
Xiaoju Yuan - National Institute for Viral Disease Control and Prevention
Pengyan Wang - Wenzhou Medical University
Ning Zhang - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Yuhuan Gong - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Chengrong Bian - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Zhaohai Wang - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Linxiang Yu - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Jin Yan - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Fanping Meng - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Changqing Bai - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Xiaoshan Wang - China National GeneBank
Xiaopan Liu - University of Chinese Academy of Sciences
Kai Gao - University of Chinese Academy of Sciences
Liang Wu - China National GeneBank
Longqi Liu - China National GeneBank
Ying Gu - China National GeneBank
Yuhai Bi - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Yi Shi - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Shaogeng Zhang - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Chen Zhu - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China
Xun Xu - China National GeneBank
Guizhen Wu - National Institute for Viral Disease Control and Prevention
George F Gao - National Institute for Viral Disease Control and Prevention
Naibo Yang - University of Chinese Academy of Sciences
William J Liu - Wenzhou Medical University
Penghui Yang - The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China. Electronic address: ypenghuiamms@hotmail.com
Publication Details: Human immunology, Vol.83(2), p.119
Publisher: Elsevier BV
Identifiers: 9924084582501921
Academic Unit: Rosenstiel Basic Medical Sciences Research Center; Department of Biology
Language: English
Resource Type: Journal article

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

Abstract

UN Sustainable Development Goals (SDGs)

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