Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin

S Penman; M Rosbash; M Penman

doi:10.1073/pnas.67.4.1878

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Journal article

Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin

S Penman, M Rosbash and M Penman

Proceedings of the National Academy of Sciences - PNAS, Vol.67(4), pp.1878-1885

12/1970

DOI: https://doi.org/10.1073/pnas.67.4.1878

PMID: 5275385

Abstract

Biological Sciences

Biochemistry

Cordycepin (3′-deoxyadenosine) suppresses the labeling of messenger RNA in HeLa cells. The drug has no effect on either the labeling of nuclear heterogeneous RNA or on the transport of messenger RNA into the cytoplasm. The results suggest that messenger RNA and nuclear heterogeneous RNA are synthesized separately, and that the transcription of messenger RNA is inhibited by the drug.

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Title: Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin
Creators: S Penman - MASSACHUSETTS INSTITUTE OF TECHNOLOGY, DEPARTMENT OF BIOLOGY, 77 MASSACHUSETTS AVENUE, CAMBRIDGE, MASS. 02139
M Rosbash - MASSACHUSETTS INSTITUTE OF TECHNOLOGY, DEPARTMENT OF BIOLOGY, 77 MASSACHUSETTS AVENUE, CAMBRIDGE, MASS. 02139
M Penman - MASSACHUSETTS INSTITUTE OF TECHNOLOGY, DEPARTMENT OF BIOLOGY, 77 MASSACHUSETTS AVENUE, CAMBRIDGE, MASS. 02139
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.67(4), pp.1878-1885
Identifiers: 9923958163001921
Academic Unit: Department of Biology; Benjamin and Mae Volen National Center for Complex Systems; Interdepartmental Program in Neuroscience
Language: English
Resource Type: Journal article

Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin

Abstract

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