Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection

Amanda C Jacobson; Ying Ma; James F Zachary; Janis J Weis; John H Weis

doi:10.1128/IAI.01920-06

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Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection

Journal article

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Peer reviewed

Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection

Amanda C Jacobson, Ying Ma, James F Zachary, Janis J Weis and John H Weis

Infection and immunity, Vol.75(4), pp.2075-2078

04/2007

DOI: https://doi.org/10.1128/IAI.01920-06

PMCID: PMC1865699

PMID: 17283093

Abstract

Host Response and Inflammation

CD21/35−/− mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35−/− mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.

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Title: Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection
Creators: Amanda C Jacobson - Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650
Ying Ma - Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650
James F Zachary - Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650
Janis J Weis - Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650
John H Weis - Division of Cell Biology and Immunology, Department of Pathology, 15 North Medical Drive East, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650
Publication Details: Infection and immunity, Vol.75(4), pp.2075-2078
Publisher: American Society for Microbiology
Identifiers: 9923987661201921
Academic Unit: Department of Biology
Language: English
Resource Type: Journal article

Mice Lacking CD21 and CD35 Proteins Mount Effective Immune Responses against Borrelia burgdorferi Infection

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