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Mn(III)-based oxidative free radical cyclizations of unsaturated 2-cyclohexenones and aldehydes
Journal article   Peer reviewed

Mn(III)-based oxidative free radical cyclizations of unsaturated 2-cyclohexenones and aldehydes

Barry B Snider and Eugenia Y Kiselgof
Tetrahedron, Vol.52(17), pp.6073-6084
04/22/1996

Abstract

Oxidative free-radical cyclizations of unsaturated 2-cyclohexenones 9a, 9b, 17, and 24 with Mn(OAc)3 afford unsaturated α′-keto radicals such as 10 that cyclize to afford bicyclic products. The major process with 2-cyclohexenone 27 is conjugate addition of acetate to form β-acetoxy α-keto radical 37. Unsaturated aldehydes 45, 57a, and 57b are oxidized to radicals that cyclize to give cyclopentane- and cyclohexanecarboxaldehdyes.

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