Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci

BENGANG Xing; Chun-Wing YU; Pak-Leung HO; Kin-Hung Chow; Terence Cheung; HONGWEI GU; ZONGWEI Cai; BING XU

doi:10.1021/jm030417q

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Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci

Journal article

Peer reviewed

Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci

BENGANG Xing, Chun-Wing YU, Pak-Leung HO, Kin-Hung Chow, Terence Cheung, HONGWEI GU, ZONGWEI Cai and BING XU

Journal of medicinal chemistry, Vol.46(23), pp.4904-4909

11/01/2003

DOI: https://doi.org/10.1021/jm030417q

PMID: 14584941

Abstract

Biological and medical sciences

Medical sciences

Antibacterial agents

Pharmacology. Drug treatments

Antibiotics. Antiinfectious agents. Antiparasitic agents

Entropy

Stiffness

Peptides and proteins

Reaction products

Metals

Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H2O)2]2+, exhibit potent activities (MIC ∼0.8 μg/mL, ∼720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

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Title: Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci
Creators: BENGANG Xing - Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong-Kong
Chun-Wing YU - Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong-Kong
Pak-Leung HO - Center of Infection and Department of Microbiology, Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong-Kong
Kin-Hung Chow - Center of Infection and Department of Microbiology, Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong-Kong
Terence Cheung - Center of Infection and Department of Microbiology, Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong-Kong
HONGWEI GU - Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong-Kong
ZONGWEI Cai - Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong-Kong
BING XU - Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong-Kong
Publication Details: Journal of medicinal chemistry, Vol.46(23), pp.4904-4909
Publisher: American Chemical Society
Identifiers: 9924013315901921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci

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