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Oxidative cleavage of α-diols, α-diones, α-hydroxy-ketones and α-hydroxy- and α-keto acids with calcium hypochlorite [Ca(OCl) 2]
Journal article   Peer reviewed

Oxidative cleavage of α-diols, α-diones, α-hydroxy-ketones and α-hydroxy- and α-keto acids with calcium hypochlorite [Ca(OCl) 2]

Stephen O Nwaukwa and Philip M Keehn
Tetrahedron letters, Vol.23(31), pp.3135-3138
1982

Abstract

α-Diols, α-diones, α-hydroxy ketones, and α-hydroxy- and α-keto acids are easily cleaved oxidatively with calcium hypochlorite. The reaction is carried out at ambient temperature in aqueous acetonitrile/acetic acid solution. The yields are good to excellent and the products, depending on the starting material, are aldehydes, ketones or acids.

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