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Palladium‐Catalyzed Tandem Reaction of Alkyne‐Based Aryl Iodides and Salicyl N‐Tosylhydrazones to Construct the Spiro[benzofuran‐3,2′‐chromene] Skeleton
Journal article   Peer reviewed

Palladium‐Catalyzed Tandem Reaction of Alkyne‐Based Aryl Iodides and Salicyl N‐Tosylhydrazones to Construct the Spiro[benzofuran‐3,2′‐chromene] Skeleton

Xue Song Shang, Nian Tai Li, Deng Yuan Li and Pei Nian Liu
Advanced synthesis & catalysis, Vol.358(10), pp.1577-1582
05/19/2016

Abstract

palladium migratory insertion spirocyclic skeletons cyclization tandem reactions
A convenient palladium‐catalyzed tandem reaction of aryl iodides and salicyl N‐tosylhydrazones has been achieved to afford a series of compounds containing the novel spiro[benzofuran‐3,2′‐chromene] scaffold in moderate to good yields. This efficient catalytic reaction, which tolerates various functional groups, combines alkyne‐based 5‐exo‐dig cyclization, palladium(II) carbene migratory insertion and intramolecular cyclization, generating three new bonds in one reaction.

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