Abstract
Nanosized calcium phosphate was prepared by a reverse microemulsion method, with a 20~40 nm diameter, which is pH-responsive, nontoxic and colloidally stable in physiological solution. Polyethylene glycol modified calcium phosphate nanoparticles shifted the zeta potential to a neutral charge, which prolonged the nanoparticle circulation time and increased cellular uptake efficacy to targeted cells. The PEG-functionalized nanoparticles exhibit a great potential for efficaciously delivering hydrophobic anticancer drug, such as paclitaxel, to cells and tumors.
