Rare HRAS alleles and susceptibility to human breast cancer

Jeffrey M Hall; Bing Huey; Jan Morrow; Beth Newman; Ming Lee; Elizabeth Jones; Christine Carter; Gertrude C Buehring; Mary-Claire King

doi:10.1016/0888-7543(90)90466-8

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Rare HRAS alleles and susceptibility to human breast cancer

Journal article

Peer reviewed

Rare HRAS alleles and susceptibility to human breast cancer

Jeffrey M Hall, Bing Huey, Jan Morrow, Beth Newman, Ming Lee, Elizabeth Jones, Christine Carter, Gertrude C Buehring and Mary-Claire King

Genomics (San Diego, Calif.), Vol.6(1), pp.188-191

01/1990

DOI: https://doi.org/10.1016/0888-7543(90)90466-8

PMID: 2406196

Abstract

HRAS oncogene locus

breast cancer

alleles

The suggestion that inherited rare alleles at the HRAS oncogene locus might be associated with susceptibility to breast cancer led us to test linkage of HRAS and the neighboring region of 11p15 to breast cancer susceptibility in 12 high-risk families. Linkage could be excluded within 17 cM of HRAS; the lod score for close linkage to HRAS was −19.9. In addition, rare HRAS alleles segregated independently of breast cancer in 8 families in which both occurred. Among unrelated breast cancer patients not selected for family history, rare HRAS alleles were slightly, but not significantly, more frequent than among controls (0.11 vs 0.04, P = 0.11). The HRAS region of 11p is not the site of a primary alteration leading to breast cancer.

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Title: Rare HRAS alleles and susceptibility to human breast cancer
Creators: Jeffrey M Hall - School of Public Health, University of California, Berkeley, California 94720 USA
Bing Huey - School of Public Health, University of California, Berkeley, California 94720 USA
Jan Morrow - School of Public Health, University of California, Berkeley, California 94720 USA
Beth Newman - School of Public Health, University of California, Berkeley, California 94720 USA
Ming Lee - School of Public Health, University of California, Berkeley, California 94720 USA
Elizabeth Jones - School of Public Health, University of California, Berkeley, California 94720 USA
Christine Carter - National Cancer Institute, Bethesda, Maryland 20892 USA
Gertrude C Buehring - School of Public Health, University of California, Berkeley, California 94720 USA
Mary-Claire King - School of Public Health, University of California, Berkeley, California 94720 USA
Publication Details: Genomics (San Diego, Calif.), Vol.6(1), pp.188-191
Publisher: Elsevier Inc
Identifiers: 9923982490401921
Academic Unit: Department of Biology
Language: English
Resource Type: Journal article

Rare HRAS alleles and susceptibility to human breast cancer

Abstract

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