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Receptor clustering: nothing succeeds like success
Journal article   Open access   Peer reviewed

Receptor clustering: nothing succeeds like success

Leslie C Griffith
Current biology, Vol.14(11), pp.R413-R415
06/08/2004
PMID: 15182686

Abstract

Receptors, Glutamate - metabolism Animals Neuronal Plasticity - physiology Synapses - metabolism Receptors, Glutamate - genetics Synapses - physiology Drosophila Neurotransmitter Agents - metabolism Presynaptic Terminals - metabolism Drosophila Proteins - genetics Mutation - genetics Neuromuscular Junction - physiology
By experimentally limiting the amount of receptor molecules available in a postsynaptic neuron in Drosophila, it has been shown that receptors can preferentially cluster opposite active zones with a high release probability. This asymmetry in receptor distribution can alter the apparent probability and calcium-dependence of neurotransmitter release.
url
https://doi.org/10.1016/j.cub.2004.05.031View
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