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Regioselectivity of the halolactonization of γ,δ-unsaturated acids
Journal article   Peer reviewed

Regioselectivity of the halolactonization of γ,δ-unsaturated acids

Barry B Snider and Madeline I Johnston
Tetrahedron letters, Vol.26(45), pp.5497-5500
1985

Abstract

Chemical Reactions Chemical Sciences
Bromolactonization of 4-hexenoic acids gives a greater percentage of δ-lactones than does iodolactonization. Substituents in the 3-position favor the formation of δ-lactones while substituents in the 6-position favor the formation of γ-lactones.

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