Abstract
Smells can arise from a source external to the body and stimulate the olfactory epithelium upon inhalation through the nares (orthonasal olfaction). Alternatively, smells may arise from inside the mouth during consumption, stimulating the epithelium upon exhalation (retronasal olfaction). Both ortho- and retronasal olfaction produce highly salient percepts, but the two percepts have very different behavioral implications. Here, we use optogenetic manipulation in the context of a flavor preference learning paradigm to investigate differences in the neural circuits that process information in these two submodalities of olfaction. Our findings support a view in which retronasal, but not orthonasal, odors share processing circuitry commonly associated with taste. First, our behavioral results reveal that retronasal odors induce rapid preference learning and have a potentiating effect on orthonasal preference learning. Second, we demonstrate that inactivation of the insular gustatory cortex selectively impairs expression of retronasal preferences. Thus, orally sourced (retronasal) olfactory input is processed by a brain region responsible for taste processing, whereas externally sourced (orthonasal) olfactory input is not.
•Retronasal, but not orthonasal, odors facilitate rapid preference learning•Preferences for retronasal odors are not expressed orthonasally•Retronsasal odors potentiate the formation of orthonasal preferences•Inactivating taste cortex selectively impairs expression of retronasal preferences
Smell can arise from an external source or from inside the mouth during consumption. Here, Blankenship et al. demonstrate that orally sourced odors share processing circuitry with taste: internal, but not external, odors rapidly induce flavor preferences, the expression of which is selectively impaired by optogenetic inactivation of taste cortex.