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Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929
Journal article   Open access   Peer reviewed

Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929

Masaaki Shibuya, Barry B Snider, Yuichi Sakano, Hiroshi Tomoda, Satoshi Omura and Yutaka Ebizuka
Journal of antibiotics, Vol.58(9), pp.599-601
09/2005
DOI: https://doi.org/10.1038/ja.2005.82
PMID: 16320765

Abstract

Bridged Bicyclo Compounds, Heterocyclic - pharmacology Fungi - classification Stereoisomerism Bridged Bicyclo Compounds, Heterocyclic - chemistry Enzyme Inhibitors - chemistry Humans Intramolecular Transferases - antagonists & inhibitors Enzyme Inhibitors - pharmacology Structure-Activity Relationship Bridged Bicyclo Compounds, Heterocyclic - isolation & purification Fungi - chemistry Enzyme Inhibitors - isolation & purification
The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1 alpha-hydroxy-3alpha-(4'-oxoundec-(5' E)-enyl)-pyrrolizidine and 1beta-hydroxy-3 alpha-(4'-oxoundec-(5 'E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds.
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https://doi.org/10.1038/ja.2005.82View
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