Abstract
Biological macromolecules, living in the confines of a cell, often adopt conformations that are unlikely to occur in free space. In this paper, we investigate the effects of confinement on the shape of a semiflexible chain. Results of Monte Carlo simulations show the existence of a shape transition when the persistence length of the polymer becomes comparable to the dimensions of the box. An order parameter is introduced to quantify this behavior. A simple model is constructed to study the effect of the shape transition on the effective persistence length of the polymer.