Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters by a Catalytic Conjugate Addition

Hongming Li; Yi Wang; Liang Tang; Fanghui Wu; Xiaofeng Liu; Chengyun Guo; Bruce M Foxman; Li Deng

doi:10.1002/ange.200461923

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Journal article

Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters by a Catalytic Conjugate Addition

Hongming Li, Yi Wang, Liang Tang, Fanghui Wu, Xiaofeng Liu, Chengyun Guo, Bruce M Foxman and Li Deng

Angewandte Chemie, Vol.117(1), pp.107-110

01/2005

DOI: https://doi.org/10.1002/ange.200461923

Abstract

Cinchona alkaloids

Stereocenters

Catalysis

Organic Chemistry

Chirale Organokatalysatoren wie der gezeigte katalysieren Michael-Additionen einer Vielzahl von trisubstituierten Kohlenstoffnucleophilen an Nitroalkene, häufig mit fast perfekter Stereoselektivität (>99 % ee und >98:2 d.r.). In einem Schritt werden benachbarte quartäre und tertiäre Stereozentren mit nur Kohlenstoff- oder auch Heteroatomsubstituenten aus einfach zugänglichen Ausgangsverbindungen erhalten.

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Title: Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters by a Catalytic Conjugate Addition
Creators: Hongming Li (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Yi Wang (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Liang Tang (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Fanghui Wu (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Xiaofeng Liu (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Chengyun Guo (Author) - Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, Fax: (+1) 781-736-2516
Bruce M Foxman (Author) - Brandeis University, Department of Chemistry
Li Deng (Author) - Brandeis University, Department of Chemistry
Publication Details: Angewandte Chemie, Vol.117(1), pp.107-110
Publisher: WILEY-VCH Verlag
Number of pages: 4
Grant note: This work was supported financially by the National Institutes of Health (GM-61591) and by a Sloan Research Fellowship (L.D.).
Identifiers: 9924126823201921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters by a Catalytic Conjugate Addition

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