Structural modifications of N-arylamide oxadiazoles : Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2

Erin F Dimauro; John L Buchanan; Matthew W Martin; Susan A Tomlinson; Ryan D White; XIAO MEI Zheng; Vinod F Patel; Robert T Fremeau; Alan Cheng; Renee Emkey; Stephen A Hitchcock; LIYUE Huang; Ming Y Huang; Brett Janosky; Josie H Lee; XINGWEN LI

doi:10.1016/j.bmcl.2008.06.096

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Structural modifications of N-arylamide oxadiazoles : Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2

Journal article

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Structural modifications of N-arylamide oxadiazoles : Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2

Erin F Dimauro, John L Buchanan, Matthew W Martin, Susan A Tomlinson, Ryan D White, XIAO MEI Zheng, Vinod F Patel, Robert T Fremeau, Alan Cheng, Renee Emkey, …

Bioorganic & medicinal chemistry letters, Vol.18(15), pp.4267-4274

2008

DOI: https://doi.org/10.1016/j.bmcl.2008.06.096

PMID: 18640038

Abstract

Biological and medical sciences

Medical sciences

Miscellaneous

Neuropharmacology

Neurotransmitters. Neurotransmission. Receptors

Pharmacology. Drug treatments

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Title: Structural modifications of N-arylamide oxadiazoles : Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2
Creators: Erin F Dimauro - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
John L Buchanan - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Matthew W Martin - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Susan A Tomlinson - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Ryan D White - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
XIAO MEI Zheng - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Vinod F Patel - Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Robert T Fremeau - Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
Alan Cheng - Amgen
Renee Emkey - Department of HTS and Molecular Pharmacology, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Stephen A Hitchcock - Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
LIYUE Huang - Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Ming Y Huang - Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
Brett Janosky - Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
Josie H Lee - Department of HTS and Molecular Pharmacology, Amgen Inc., One Kendall Square, Building 1000, Cambridge, MA 02139, United States
XINGWEN LI - Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
Publication Details: Bioorganic & medicinal chemistry letters, Vol.18(15), pp.4267-4274
Publisher: Elsevier
Identifiers: 9924086768801921
Academic Unit: Rabb School of Continuing Studies, Division of Graduate Professional Studies
Language: English
Resource Type: Journal article

Structural modifications of N-arylamide oxadiazoles : Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2

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