Abstract
The tricyclic hydroxy imidazolidinone was converted to chaetominine in seven steps in 22% overall yield. The key step was the construction of the delta-lactam by heating an amino ester with a catalytic amount of DMAP in toluene at reflux.
- Title
- Synthesis of (-)-chaetominine
- Creators
- Barry B Snider - Department of Chemistry MS 015, Brandeis University, Waltham, MA 02454-9110, USA. snider@brandeis.eduXiaoxing Wu
- Publication Details
- Organic letters, Vol.9(23), pp.4913-4915
- Publisher
- United States
- Grant note
- R01 GM050151-14 / NIGMS NIH HHS R01 GM050151 / NIGMS NIH HHS GM 50151 / NIGMS NIH HHS
- Identifiers
- 9923958224201921
- Copyright
- © 2007 American Chemical Society
- Academic Unit
- Department of Chemistry
- Language
- English
- Resource Type
- Journal article