Synthesis of the hindered N,N,N′-trisubstituted guanidine moiety of martinelline and martinellic acid

Barry B Snider; Sean M O'Hare

doi:10.1016/S0040-4039(01)00206-4

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Journal article

Synthesis of the hindered N,N,N′-trisubstituted guanidine moiety of martinelline and martinellic acid

Barry B Snider and Sean M O'Hare

Tetrahedron letters, Vol.42(13), pp.2455-2458

2001

DOI: https://doi.org/10.1016/S0040-4039(01)00206-4

Abstract

alkaloids

cyanides

guanidines

Organic Chemistry

Hindered guanidines can be prepared by reaction of cyanamides with amines in hexafluoroisopropanol at 90–120°C. This sequence was used for preparing guanidinium acid 21 as a model for martinellic acid.

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Title: Synthesis of the hindered N,N,N′-trisubstituted guanidine moiety of martinelline and martinellic acid
Creators: Barry B Snider (Author) - Brandeis University, Department of Chemistry
Sean M O'Hare (Author)
Publication Details: Tetrahedron letters, Vol.42(13), pp.2455-2458
Publisher: Elsevier Ltd
Identifiers: 9924131321301921
Academic Unit: Department of Chemistry
Language: English
Resource Type: Journal article

Synthesis of the hindered N,N,N′-trisubstituted guanidine moiety of martinelline and martinellic acid

Abstract

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