The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

Francesca Pignoni; Birong Hu; Kenton H Zavitz; Jian Xiao; Paul A Garrity; S.Lawrence Zipursky

doi:10.1016/S0092-8674(00)80480-8

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The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

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The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

Francesca Pignoni, Birong Hu, Kenton H Zavitz, Jian Xiao, Paul A Garrity and S.Lawrence Zipursky

Cell (Cambridge), Vol.91(7), pp.881-891

12/26/1997

DOI: https://doi.org/10.1016/S0092-8674(00)80480-8

PMID: 9428512

Abstract

Drosophila eye development

vertebrates

invertebrates

sine oculis(so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless(Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.

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Title: The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development
Creators: Francesca Pignoni - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Birong Hu - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Kenton H Zavitz - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Jian Xiao - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Paul A Garrity - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
S.Lawrence Zipursky - Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Publication Details: Cell (Cambridge), Vol.91(7), pp.881-891
Publisher: Elsevier Inc
Identifiers: 9923980283701921
Academic Unit: Benjamin and Mae Volen National Center for Complex Systems; Interdepartmental Program in Neuroscience; Department of Biology
Language: English
Resource Type: Journal article

The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

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